background

BioE Graduate Seminars

Event Introduction

Decode and reprogram the yeast genome

About the speaker

Professor Junbiao Dai is currently the deputy director of Institute of Synthetic Biology (iSynBio), Shenzhen Institutes of Advanced Sciences (SIAT), Chinese Academy of Sciences (CAS). He received his Bachelor degree from Nanjing University in 1997, Master of Science in Biology from Tsinghua University in 2000 and PhD in Molecular, Cellular and Developmental Biology from Iowa State University in 2006. He was a post-doctoral fellow at the Johns Hopkins University School of Medicine before joining the faculty in School of Life Sciences at Tsinghua University in 2011.
His research interests lie in synthetic biology using different model organisms, focusing on development of new technologies for genes synthesis, assembly and synthetic genomics. He’s one of the key members in synthetic yeast consortium (Sc2.0) and has finished the synthesis of the largest yeast chromosome XII. Dr. Dai have published many peer-reviewed articles in prestigious journals such as Cell, Nature, Science, Molecular Cell, PNAS and Nucleic Acids Res and hold eight patents. He is the winner of Albert Lehninger Research Award from Johns Hopkins University, the Thousand Talent Program for Young Outstanding Scientists, Newton Advanced Fellowship and C.C. Tan Life Science Innovation Award. In 2017, He was awarded the National Science Fund for Distinguished Young Scholars.

Abstract
Facilitated by advances in technologies for DNA synthesis and assembly, the entire genome of an organism, from viruses to bacteria, has now become the target of redesign and reprogramming. The synthesis of first eukaryote, Saccharomyces cerevisiae, genome (Sc2.0) is near completion, tackled by an international consortium. Sets of design features were grafted into the Sc2.0 genome to promote deeper understanding of genome function. For example, a system called synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) is incorporated to probe the structural rule, gene content and plasticity of the yeast genome, which subsequently generated many new discoveries. In this talk, I will introduce the next version of the designed yeast genome including the construction of a mega-essential chromosome and strategies to build a highly simplified genome. 

1

Tuesday

March 2022

11.30

AM

KSA

Online

Venue: Click here

The Leads

Speakers and Invites

×

Ready to join with us?

Follow Us