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Meet The Team

Assistant Professor, Bioengineering

Fabian Schmidt

fabian.schmidt@kaust.edu.sa

Biological and Environmental Science and Engineering Division (BESE)

https://bese.kaust.edu.sa/

Center membership :

Smart Health Initiative

Orcid:

https://orcid.org/0000-0001-7731-6685

Linkedin account: https://www.linkedin.com/in/fs335/

 


 

Fabian received his Ph.D. from Cambridge University, UK. Subsequently, he joined the Hatziioannou & Bieniasz lab at Rockefeller University in New York, where he increasingly focused on translation aspects of virus-host relationships. He joined KAUST in October of last year as a BioE program core member and part of the KSHI.

FocusAndTechnologyAreas

​Postdoc at Rockefeller University, USA, 2014 - 2019

Ph.D. Virology, Cambridge University, UK, 2014

German Diplom in Biology, Universität Bielefeld, Germany, 2007

Prof. Fabian Schmidt is fascinated by the power of viral adaptation and view 'Virus Learning' as a biological analogue to 'Machine Learning'. Moreover, he is certain that by synergizing these two approaches in automatic processing pipelines, revolutionary improvements can be made at the intersection of synthetic biology and biomedical sciences.

At KAUST, his team will start by tackling a major bottleneck that flaws the manufacturing of viral gene therapy vector productions. These vectors are key to accessing cell types and organs in the human body for medical interventions. Yet, manufacturing remains difficult and inefficient even for the most commonly used vector format: Adeno-associated virus vectors (AAVs).

Using synthetic biology approaches, they will work on innovative and scalable platforms that address these shortcomings.

  • ​Schmidt F, Muecksch F, Weisblum Y, Da Silva J, Bednarski E, Cho A, Wang Z, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD. Plasma neutralization of the SARS-CoV-2 omicron variant. New England Journal of Medicine 2021
  • Schmidt F, Weisblum Y, Rutkowska M, Poston D, Da Silva J, Zhang F, Bednarski E, Cho A, Schaefer-Babajew DJ, Gaebler C, Caskey M, Nussenzweig MC, Hatziioannou T, Bieniasz PD. High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape. Nature 2021
  • Wang Z, Schmidt F, Weisblum Y, Muecksch F, Barnes CO, Finkin S, Schaefer-Babajew D, Cipolla M, Gaebler C, Lieberman JA, Oliveira TY, Yang Z, Abernathy ME, Huey-Tubman KE, Hurley A, Turroja M, West KA, Gordon K, Millard KG, Ramos V, Da Silva J, Xu J, Colbert RA, Patel R, Dizon J, Unson-O'Brien C, Shimeliovich I, Gazumyan A, Caskey M, Bjorkman PJ, Casellas R, Hatziioannou T, Bieniasz PD, Nussenzweig MC. mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants. Nature 2021
  • Schmidt F., Weisblum Y., Muecksch F., Hoffmann H.-H., Michailidis E., Lorenzi J. C. C., Mendoza P., Rutkowska M., Bednarski E., Gaebler C., Agudelo M., Cho A., Wang Z., Gazumyan A., Cipolla M., Caskey M., Robbiani D. F., Nussenzweig M. C., Rice C. M., Hatziioannou T., & Bieniasz P. D.. Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses. Journal of Experimental Medicine 2020
  • Weisblum Y., Schmidt F., Zhang F., DaSilva J., Poston D., Lorenzi J. C., Muecksch F., Rutkowska M., Hoffmann H.-H., Michailidis E., Gaebler C., Agudelo M., Cho A., Wang Z., Gazumyan A., Cipolla M., Luchsinger L., Hillyer C. D., Caskey M., Robbiani D. F., Rice C. M., Nussenzweig M. C., Hatziioannou T., & Bieniasz P. D.. Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants. eLife 2020

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