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Meet The Team

Professor, Bioengineering

Stefan Arold

stefan-arold
Email

stefan.arold@kaust.edu.sa

Biological and Environmental Science and Engineering Division (BESE)

https://bese.kaust.edu.sa

Center membership, Computational Bioscience Research Center

https://cemse.kaust.edu.sa/cbrc/people/person/stefan-arold

Structural Biology and Engineering (Stube)

https://strube.cbrc.kaust.edu.sa/

Faculty

https://www.kaust.edu.sa/en/study/faculty/stefan-arold

Orcid

https://orcid.org/0000-0001-5278-0668

Research Interests

Professor Arold’s research interests are focused on integrative structural biology based on hybrid approaches. His work involves inferring structure and function of macromolecular assemblies, to enhance computational methods for functional annotation of genes (system-wide or focused), and to design and engineer molecules with desired properties (switches, genetic/epi-genetic regulators, detectors).

 

FocusAndTechnologyAreas

Affiliations

Education Profile

  • Habilitation, University of Montpellier, France, 2004
  • Postdoctoral Fellow, University of Oxford, UK, 1998
  • PhD, University of Montpellier, France, 1998
  • MSC, Joseph Fourier University, Grenoble, France, 1994

Selected Publications

  • Brami-Cherrier K, Gervasi N., Arsenieva D, Walkiewicz K., Boutterin MC, Ortega A, Leonard PG, Seantier B, Gasmi L, Bouceba T, Noble MEM, Girault JA, Arold ST. (2014) FAK dimerization controls its kinase-dependent functions at focal adhesions. EMBO J. 3,356-370. 
  • Suen KM, Lin CC, George R, Melo FA, Biggs, ER, Ahmed Z, Drake MN, Arur S, Arold ST, Ladbury JE (2013) Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nat. Struct. Mol Biol. 20, 620-7
  • Lin C.C., Melo F.A., Ghosh R., Suen K.M, Stagg L.J., Kirkpatrick J., Arold S.T., Ahmed A., Ladbury J.E. (2012) Inhibition of basal FGF receptor signaling by Grb2. Cell, 149, 1514-24
  • Ladbury J.E., Arold S.T. (2012) Noise in cellular signaling pathways: causes and effects. Trends Biochem Sci, 37, 173-8
  • Arold S.T. (2011) How focal adhesion kinase achieves regulation by linking ligand binding, localization and action. Curr Opin Struct Biol. 21, 808-13
  • Declerck N., Bouillaut L., Chaix D., Rugani N., Slamti L., Hoh F., Lereclus D. & Arold S.T. (2007) Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria. PNAS, 104, 18490-5

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